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PI介绍 > 陈雄文

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研究领域
教育经历
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陈雄文博士

电话：022-83336670

电邮：xiongwenchen@tmu.edu.cn

1) 钙信号和β-肾上腺能信号在心血管疾病和代谢疾病的发生、发展和治疗中作用；

2) 基因和干细胞治疗心血管疾病的研究。

实验室成员

1997-2003	美国天普大学，生理学，博士
1994-1997	中国农业大学，动物生理与生物化学生物学，硕士
1990-1994	中国农业大学，动物生理与生物化学生物学，学士

专业经验

2020- 今	天津医科大学药学院，院长，教授
2020-2020	美国天普大学心血管病研究中心生理学系，教授（tenured）
2013-2018	第三军医大学第三附属医院大坪医院心内科，客座教授
2014-2020	美国天普大学心血管病研究中心生理学系，副教授（tenured）
2008-2014	美国天普大学心血管病研究中心生理学系，助理教授（tenure track）
2006-2008	美国天普大学心血管病研究中心生理学系，助理教授（research track）
2003-2006	美国天普大学心血管病研究中心生理学系，博士后

获得荣誉

2009	美国心脏协会资深会员（FAHA, 2009, AHA）
2007	美国心力衰竭协会（HFSA）Jay N. Cohn 青年科学家奖
2006	美国心脏协会（AHA）Melvin L. Marcus 青年科学家最终优胜者
2002	美国心脏协会（AHA）青年科学家奖
2001	国际心脏研究协会（ISHR）最佳简报奖（Best Poster Award， 2001）
2022	天津市长期咨询专家
2013	青年千人

科研基金

2021-2024	科技部，国家重点研发计划 2021YFF0702103
2021-2024	国家自然科学基金面上项目 82070428
2019-2021	ADA Grant#: 1-19-IBS-210
2018-2022	NIH 1R01 1R01HL140071-01A1
2017-2020	国家自然科学基金面上项目 31671178
2015-2018	国家自然科学基金面上项目31471089
2013-2018	NIH 2R012R01HL088243-06A1
2013-2013	Pennsylvania Department of Health Grant SAP Number: 4100062
2012-2017	NHLBI/NIH 1P011P01HL108806-01A1
2007-2012	NHLBI/NIH 1R011R01HL088243-01
2007-2010	AHA Scientist Development Grant 0730347N
2009-2011	NHLBI/NIH 3R013R01HL088243-03S

1. Zhang X*, Li Y*, Zhang X, Piacentino V 3rd, Harris DM, Berretta R, Margulies KB, Houser SR*, Chen X*. A low voltage activated Ca2+ current found in a subset of human ventricular myocytes. Channels (Austin). 2020 Dec;14(1):231-245.

2. Liu C*, Ke P, Zhang J, Zhang X, Chen X*. Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A. Front Physiol. 2020 Nov 25;11:574030. doi: 10.3389/fphys.2020.574030. eCollection 2020.

3. Jining Yang*; Xiaoying Zhang; Long Yi; Ling Yang; Wei Eric Wang; Chunyu Zeng; Mantian Mi*, Xiongwen Chen*. Hepatic PKA inhibition accelerates the lipid accumulation in liver. Nutr Metab (Lond). 2019 Oct 11;16:69.

4. Ying Zhang*, Wei Eric Wang*, Xiaoying Zhang*, Ying Li*, Biyi Chen, Chong Liu， Xiaojie Ai, Xiaoxiao Zhang, Ying Tian, Chen Zhang, Mingxin Tang, Christopher Szeto, Xiang Hua, Mingxin Xie, Chunyu Zeng, Yingjie Wu, Lin Zhou, Weizhong Zhu, Daohai Yu, Steven R. Houser,Xiongwen Chen* . Cardiomyocyte PKA Ablation Enhances Basal Contractility while Eliminates Cardiac β-Adrenergic Response without Adverse Effects on the Heart. Circ Res. 2019 Jun 7;124(12):1760-1777.

5. Xiongwen Chen*, Xiaoying Zhang, Steven R. Houser, Jonathan Soboloff*. Acetylation of SERCA2a, another target for heart failure treatment? Circ Res. 2019 Apr 26;124(9):1285-1287.

6. Li Y*, Zhang X*, Zhang C, Zhang X, Li Y, Qi Z, Szeto C, Tang M, Peng Y, Molkentin JD, Houser SR, Xie M*, Chen X*. Increasing T-Type calcium channel activity by β-adrenergic stimulation contributes to β-adrenergic regulation of heart rates. J Physiol. 2018 Apr 1;596(7):1137-1151.

7. Li Z*, Li Y*, Zhang L*, Zhang X, Sullivan R, Ai X, Szeto C, Cai A, Liu L, Xiao W, Li Q, Ge S*, Chen X*. Reduced Myocardial Reserve in Young X-Linked Muscular Dystrophy Mice Diagnosed by Two-Dimensional Strain Analysis Combined with Stress Echocardiography. J Am Soc Echocardiogr. 2017 May 13. pii: S0894-7317(17)30187-6.

8. Wang WE*, Li L*, Xia X*, Fu W, Liao Q, Lan C, Yang D, Chen H, Yue R, Zeng CS, Zhou L, Zhou B, Duan DD, Chen X*, Houser SR*, Zeng C*. Dedifferentiation, Proliferation and Redifferentiation of Adult Mammalian Cardiomyocytes After Ischemic Injury. Circulation. 2017 Jun 22.

9. Chen X*, O'Connell TD, Xiang YK*. With or Without Langendorff: A New Method for Adult Myocyte Isolation to Be Tested With Time. Circ Res. 2016 Sep 30;119(8):888-90.

10. Zhang X*, Ai X*, Nakayama H; Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, and Chen X*. Persistent Increases in Ca2+ Influx through Cav1.2 Shortens Action Potential And Causes Ca2+ Overload-induced Afterdepolarizations and Arrhythmias. Basic Res Cardiol. 2016 Jan;111(1):4.

11. Li Y*, Zhang S*, Zhang X, Li J, Ai X, Zhang L, Yu D, Ge S, Peng Y*, Chen X*. Blunted cardiac beta-adrenergic response as an early indication of cardiac dysfunction in Duchenne muscular dystrophy. Cardiovasc Res. 2014 Jul 1;103(1):60-71.

12. Zhang X*, Szeto C, Gao E, Tang M, Jin J, Fu Q, Makarewich C, Ai X, Li Y, Tang A, Wang J, Gao H, Wang F, Ge XJ, Kunapuli SP, Zhou L, Zeng C, Xiang KY, Chen X*. Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling. Circ Res. 2013 Feb 1;112(3):498-509.

13. Li Y*, Wang F*, Zhang X, Qi Z, Tang M, Szeto C, Li Y, Zhang H, Chen X*. β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A. PLoS One. 2012;7(7):e39965.

14. Raake PW*, Zhang X, Vinge LE, Brinks H, Gao E, Jaleel N, Li Y, Tang M, Most P, Dorn GW 2nd, Houser SR, Katus HA, Chen X*, Koch WJ*. Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction. Circulation. 2012 May 1;125(17):2108-18.

15. Liu S*, Li Y*, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y,Chen X* , Xiang YK*. Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6578-83.

16. Tang M*, Zhang X*, Li Y, Guan Y, Ai X, Szeto C, Nakayama H, Zhang H, Ge S, Molkentin JD, Houser SR, Chen X*. Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H519-28.

17. Jaleel N*, Nakayama H*, Chen X*, Kubo H*, Macdonnell S, Zhang H, Berretta R, Robbins J, Cribbs L, Molkentin JD, Houser SR*. Ca2+ Influx Through T- and L-Type Ca2+ Channels Have Different Effects on Myocyte Contractility and Induce Unique Cardiac Phenotypes. Circ Res. 2008 Nov 7;103(10):1109-19.

18. Nakayama H*, Chen X*, Baines CP, Klevitsky R, Zhang X, Zhang H, Jaleel N, Chua BH, Hewett TE, Robbins J, Houser SR*, Molkentin JD*. Ca2+ and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Invest. 2007 Sep;117(9):2431-44.

19. Chen X*, Wilson RM*, Kubo H, Berretta RM, Harris DM, Zhang X, Jaleel N, Macdonnell SM, Bearzi C, Tillmanns J, Trofimova I, Hosoda T, Mosna F, Cribbs L, Leri A, Kajstura J, Anversa P, Houser SR*. Adolescent Feline Heart Contains a Population of Small, Proliferative Ventricular Myocytes With Immature Physiological Properties. Circ Res. 2007 Mar 2;100(4):536-44.

20. Chen X*, Zhang X, Kubo H, Harris DM, Mills GD, Moyer J, Berretta R, Telemaque Potts S, Marsh JD, Houser SR*. Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes. Circ Res. 2005 Nov 11;97(10):1009-17

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